Sanjana's best friend at college is murdered. She was in love with a business tycoon named Nik Sethi, and Sanjana is certain that he killed her. In an effort to find proof, she decides to get close to him.
Good looking and rich, Nik falls in love with Sanjana instantly, but a month later, when he accidentally discovers her real agenda, he throws her out of his life. Determined to nail him, Sanjana's desperation exceeds all limits when she realizes that she, too, like her friend, has fallen in love with a killer.
After she escapes an attack one night, Sanjana quits college and goes into hiding. Now her only ambition is to punish the killer, and her only weapon is her body. In a desperate last attempt, she uses herself as bait and pursues her best plan. There are only two options: she becomes a victim or she becomes a victor.
Through the story of Sanjana and Nik, In Love with Simran explores the boundaries of the basic instincts of the young: love, sex, trust and survival.